Customizable Platform Technology
Enables high affinity monoclonal antibody discovery
Science
Customizable Platform Technology Enables high affinity monoclonal antibody discovery
Components of Treatment
Cessation has pioneered an anti-fentanyl monoclonal antibody treatment that represents a novel approach to addressing fentanyl associated risks.
Components of Treatment
Cessation has pioneered an anti-fentanyl monoclonal antibody treatment that represents a novel approach to addressing fentanyl associated risks.
Benefits to Cessation's Treatment
Cessation’s anti-fentanyl monoclonal antibody treatment is different from current options. It is designed to provide ongoing and durable protection from overdose. It captures fentanyl in the blood, stops it before it gets to the brain, and prevents it from exerting it’s harmful effects.
Enters the blood stream
eventually reaching the brain
Capture fentanyl in the blood stopping
it before reaching the brain
Benefits to Cessation's Treatment
Cessation’s anti-fentanyl monoclonal antibody treatment is different from current options. It is designed to provide ongoing and durable protection from overdose. It captures fentanyl in the blood, stops it before it gets to the brain, and prevents it from exerting it’s harmful effects.
Enters the blood
stream eventually
reaching the brain
Capture fentanyl
in the blood
stopping it before
reaching the brain
Days of Protection
A single administration of CSX-1004 provides durable protection from fentanyl for >1 month in nonhuman primate models
Mechanism of Opioid-Induced Overdose Death
Fentanyl can lead to life threatening respiratory depression within 2-3 minutes of administration.
Opioids also bind to opioid receptors in the
brain stem and suppress or stop the breathing
reflex, potentially leading to overdose death.
Opioids, including fentanyl, activate “reward centers”
in brain to produce euphoria.
Mechanism of Opioid-Induced Overdose Death
Fentanyl can lead to life threatening respiratory depression within 2-3 minutes of administration.
Opioids also bind to opioid receptors
in the brain stem and suppress or stop
the breathing reflex, potentially leading
to overdose death.
Opioids, including fentanyl,
activate “reward centers” in
brain to produce euphoria.
Monoclonal antibodies Effects on fentanyl
The antibodies capture fentanyl in the blood and stop it before it gets to the brain keeping it from exerting it’s harmful effects.
Monoclonal antibodies sequester drugs of abuse in the bloodstream, preventing them from affecting the brain. The use of monoclonal antibodies allows for optimal control of dosing, predictable exposure over time, and immediate protection after treatment. The monoclonal antibody is restricted to the bloodstream, and thus is devoid of abuse potential and psychiatric side-effects common to other treatments for substance use disorders.